The Museum was founded in 1913 and moved to its present location in 1955. The museum is home to three collections.

Cuban Art from the 17th century to the present, features works by Miguel Melero, Estaban Chartrand, Armando Menocal, Victor Manuel, Portocarrero, Wifredo Lam, Servando Cabrerra, Amelia Pelaez and others.

European Painting offers originals by Rubens, Murillo, Zurbaran, Velazquez, Goya, Hans Memling and others.

Ancient Art showcases the finest collection of Egyptian, Greek and Roman pieces in Latin America, including funeral portraits from Al Fayyum of the 2nd to the 4th centuries.